All cartoon illustrations differ in frames and individuals’ understanding of their messages. This study examined three Nigerian daily newspapers: Daily sun, Vanguard and the Nation to ascertain the frames of Ebola cartoon, the perception of the cartoon by the audience, and the interpretation of the cartoon messages. The researcher situates his work on the “play theory” which asserts that we use the media for our satisfaction, and that media contents bring changes in our lives. Qualitative content analysis and focus group discussion methods were used as methodology of the study. The study covered a period of one month from August 1st, 2014 to August 31st, 2014. The findings of the study revealed that most cartoons on Ebola virus had the fear frames. Also, most of the audience couldn’t interpret the cartoon messages due to lack of understanding of the drawings. It was recommended among others, that cartoonists should make their drawings less technical but simple for easy understanding by the audience.
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